01 / EVIDENCE
Evidence Synthesis & Assessment
Systematic, rapid and targeted reviews; critical appraisal; certainty assessment; and the interpretation of direct and indirect evidence.
INDEPENDENT RESEARCH FOUNDATION / CANADA
Evidence synthesis · Research methodology · Clinical pharmacology · Pharmacotherapy
Advancing evidence for better decisions in medicines and healthcare.
An independent Canadian not-for-profit research organization connecting rigorous evidence, scientific methods and decisions that matter to patients and health systems.
WHAT WE WORK ON
Connecting evidence, methods and clinical decisions.
Our work brings together the scientific perspectives needed to evaluate complex questions about medicines and health care.
02 / THERAPEUTICS
Clinical Pharmacology & Precision Therapeutics
Clinical evidence across pharmacotherapy, drug monitoring, pharmacogenomics, pharmacokinetics, pharmacodynamics and medication safety.
03 / METHODS
Methods & Research Design
GRADE methodology, research questions, study design and methodological approaches to evidence generation and appraisal.
04 / DECISIONS
Evidence Translation & Decision Support
Evidence-to-Decision thinking, guideline methodology, knowledge translation and support for transparent health care decisions.
HOW WE THINK
Some decisions cannot be answered by one type of evidence.
Drug treatment questions frequently demand careful integration across complementary evidence streams.
From different sources of evidence to clearer judgments.
Randomized trials, observational studies, pharmacokinetic and pharmacodynamic research, pharmacogenomic evidence and real-world data can each contribute distinct insights. Understanding their strengths, limitations and applicability is essential.
Explore our approachRandomized trialsObservational studiesPK / PD & PGxReal-world evidenceEvidence assessmentInformed decisions
INDEPENDENT ACADEMIC INITIATIVES
Two initiatives. Distinct purposes.
These academic initiatives are presented for their scientific relevance. They retain their own academic independence.
METHODOLOGY
Clinical Pharmacology GRADE Group
Advances approaches to assessing certainty of evidence and other methodological questions in clinical pharmacology.
Explore the initiativeGUIDELINES & APPLICATION
International Clinical Pharmacology EBM Group
Focuses on clinical practice guidelines, evidence-informed pharmacotherapy, implementation and international academic collaboration.
Explore the initiativeCAPTURE provides this website and describes these initiatives without claiming ownership or control over their academic decisions.
SCIENTIFIC INDEPENDENCE
Integrity is a condition of collaboration.
Commissioned research and academic collaboration must preserve transparent methods, appropriate attribution and independence of scientific judgments.
Research questions and methods
Transparent interpretation of evidence
Independent recommendations and conclusions
COLLABORATE
Work together on evidence that matters.
We welcome thoughtful collaborations across academic, clinical, public-sector, non-profit and life-sciences settings.