SYNTHESIS
Systematic, rapid & targeted reviews
Structured searching, appraisal and synthesis calibrated to the question and intended use.
CAPTURE / Research & Evidence
Building dependable evidence for complex decisions.
CAPTURE focuses on evidence synthesis, GRADE certainty assessment, HTA-oriented evidence, research design and translation into decisions.
EVIDENCE SYNTHESIS
From the research question to the certainty of evidence.
Evidence products should be tailored to the clinical, policy or research decision they will inform.
ASSESSMENT
GRADE & evidence certainty
Explicit judgments about the certainty of evidence, including important challenges involving indirect evidence.
MAPPING
Evidence landscapes & gaps
Mapping available evidence, identifying limitations and clarifying priorities for new studies.
DECISION SUPPORT
HTA-oriented evidence & translation
Evidence summaries and methodological input for clinical, health technology and policy discussions.
RESEARCH METHODOLOGY
Methods matter when evidence is incomplete or indirect.
Methodological research can help us make more defensible judgments about benefits, harms and applicability.
Questions we take seriously
- When can indirect clinical and pharmacological evidence support a decision?
- How should adverse drug events be causally attributed and assessed?
- What can very large observed effects tell us in small populations?
- How can research design improve evidence needed for future decisions?
RESEARCH DESIGN
Strengthening the next generation of evidence.
Research questions and study designs should address decision-relevant uncertainties.
Our areas of interest include trial and observational study design, clinical pharmacology methods, evidence gaps, and rigorous approaches to synthesis and knowledge translation.